Research

Doctors at City Eye Centre are committed to supporting research, education and clinical trials with the purpose of developing the best possible future outcomes for our patients.

 

Clinical Trials

 

·         Vitrase Trial: double blind world wide drug trial into the use of vitrase for vitreous hemorrhage

·         AvastinTrial: microbiological contamination in vials of bevacizumab used for multiple intravitreal injections

·         Candesartan Trial: world wide drug trial in conjunction with the RBH endocrinology department to see if candesartan decreases diabetic retinopathy

·         Liver Trial: drug trials for new treatments for hepatitis C (Eltrombopaq trial)

·         ICG Trial for internal limiting membrane peeling in macular hole surgery

·         PVR Trial: a randomised controlled trial of combined 5-fluorouracil and low molecular weight heparin in management of established proliferative vitreoretinopathy (PVR study group)

·         Combigan Early Experience Data (CEED)/Allergan Trial: clinical trial on efficacy and tolerability of combination of bromonidine and timolol (Combigan)

·         Serum eye drop Trial: clinical trial on efficacy and tolerability of autologous serum drops for severe dry eye syndrome

·         Interferon Alfa-2b Trial: clinical trial on efficacy and tolerability of interferon for recalcitrant ocular surface squamous neoplasia

 

 

Publications

 

Dr Lawrence Lee

 

1.       Chen JC, Lee LR. (2008) Clinical spectrum of lamellar macular defects including pseudoholes and pseudocysts defined by optical coherence tomography. British Journal of Ophthalmology; 92(10): 1342-1346.

2.       Lee LR, Chen JC. (2008) Modified Cow-Hitch Suture Fixation. Cataract & Refractive Surgery Today Europe; 3(8): 14-15.

3.       Chen JC, Lee LR. (2008) A more coherent relationship to optical coherence tomography scans and retinal anatomy. Clinical and Experimental Optometry; 91(3): 328-329.

4.       Chen JC, Lee LR, Vorster, S. (2008) Spontaneous resolution of a stage III macular hole: a long-term follow-up with OCT. Retinal Cases & Brief Reports; 2(3):225-227.

5.       Chen JC, Lee LR, Vorster, S. (2008) Posterior Placoid Chorioretinitis: an unusual ocular manifestation of syphilis. Clinical Ophthalmology; 2(3): 669-674.

6.       Chen X, Lee LR. (2008) Microcannula breakage in 25-gauge transconjunctival sutureless vitrectomy. Retinal Cases and Brief Reports; 2(1):65-66.

7.       Smith TC, Lee LR. (2008) Rate of microbiological contamination in vials of bevacizumab used for multiple intravitreal injections. Retinal Cases and Brief Reports 2008; 2(2):133-135.

8.       Chen JC, Lee LR. (2007) Clinical applications and new developments of optical coherence tomography: an evidence-based review. Clinical and Experimental Optometry; 90(5); 317-335. (Issue Cover)

9.       Chen JC, Lee LR, Gass JDM. (2006) Choroidal osteoma – evidence of progression and decalcification over 20 years. Clinical and Experimental Optometry; 89(2): 90-94. (Issue Cover)

10.   Sii F, Lee LR. (2006) Retinopathy associated with photodynamic therapy for treatment of idiopathic choroidal neovascularisation. Clinical Experimental Ophthalmology; 34(2): 184-186.    

11.   Hann JV, Lee LR. (2006) Macular thickness after cataract surgery with intracameral cefuroxime. Journal of Cataract and Refractive Surgery; 3294: 545.

12.   Chen JC, Lee LR. (2005) Central serous chorioretinopathy and bullous retinal detachment: a rare association. Clinical Experimental Optometry; 88(4): 248-252.

13.   Sii F, Lee LR. (2005) Triamcinolone for AMD in cataract surgery. Ocular Surgery News.

14.   Rofail M, Lee LR, Whitehead K. (2005) Conjunctival benign reactive lymphoid neoplasia associated with myopic scleral thinning. Clinical Experimental Ophthalmology; 33(1): 73-75.

15.   Rofail M, Lee LR. (2005) Perfluoro-n-octane as a post-operative vitreoretinal tamponade in the management of giant retinal tears. Retina; 25(7): 897-901.

16.   Rofail M, Lee LR, Lee GA, Todd B. (2005) Suicide-related perforating injury of the globe with a nail gun. Clinical Experimental Ophthalmology; 33(3): 294-295.

17.   Feigl B, Brown B, Lovie-Kitchin JE, Lee LR. (2005) Dynamics of outer retinal function after multiple photodynamic therapies in age-related macular degeneration: a report of cases. Documenta Ophthalmologica; 111:135-148.

18.   Slaughter K, Lee LR. (2004) Macular hole surgery with and without indocyanine green assistance. Eye;18(4): 376-378.

19.   Rofail M, Lee LR, Mittellstadt H. (2004) An improved lens holder for the wide angle vitrectomy lens. Retina; 24(4): 654.

20.   Rofail M, Lee LR. (2004) Central serous chorioretinopathy in association with systemic lupus erythematosus. Ocular Surgery News; 22(14): 49.

21.   Chan F, Lee LR. (2004) Nanophthalmic cataract extraction. Clinical Experimental Ophthalmology; 32(5): 535-538.

22.   Sii F, Lee LR. (2004) Central serous retinopathy and photodynamic therapy. Ocular Surgery News.

23.   Feigl B, Lovie-Kitchin J, Brown B, Lee LR. (2004) Cone- and rod-mediated retinal function before and after multiple laser therapies in age-related macular degeneration. Investigative Ophthalmology and Visual Science (Suppl). 799.

24.   Chen JC, Lee LR. (2004) Solar retinopathy and associated optical coherence tomography findings. Clinical Experimental Optometry; 87(6): 390-393.

25.   Slaughter K, Lee LR. (2003) Globe perforation following peribulbar injection. Clinical Experimental Ophthalmology; 31(3): 265-267.

26.   Hilford DJ, Lee LR. (2002) Here’s Egg in your Eye: An unusual penetrating eye injury. Archives of Ophthalmology; 5: 666-667. (Issue Cover)

27.   Lee LR, Gass JDM. (1998) Choroideremia. Australian & New Zealand Journal of Ophthalmology. (Issue Cover)

28.   Challa JK, Hunyor ABL, Playfair J, Gregory-Roberts J, Lee LR. (1998) External argon laser choroidotomy for subretinal fluid drainage. Australian & New Zealand Journal of Ophthalmology; 26(1): 37-40.

29.   Lee GA, Lee LR, Gole G. (1998) Angle-Closure Glaucoma Following Laser Treatment for Retinopathy of Prematurity: A Case Report. Journal of Paediatric Ophthalmology and Strabismus; 6: 383-384.

30.   Lee GA, Lee LR, Gole GA. (1998) Angle-closure glaucoma after laser treatment for retinopathy of prematurity. J AAPOS; 2(6): 383-384.

31.   Lee LR, O’Hagan S, Dal Pra M. (1997) Aeromonas Sobria Endophthalmitis. Australian & New Zealand Journal of Ophthalmology; 25(4): 299-300.

32.   Lee LR, Sullivan TJ, Vandeleur K. (1997) Scleral Exoplant Exposure Secondary to Orbital Squamous Cell Carcinoma. Australian & New Zealand Journal of Ophthalmology; 25: 75-77.

33.   Lee LR, Readshaw G, Hirst LW. (1996) Keratoconus: The Clinical Experience of a Brisbane Ophthalmologist. Ophthalmic Epidemiology; 3(3): 119-125.

34.   Lee LR, Briner AM. (1996) Intralenticular Metallic Foreign Body. Australian & New Zealand Journal of Ophthalmology; 24(4): 361-363.

35.   Lee LR, Hirst LW, Readshaw G. (1995) Clinical Detection of Unilateral Keratoconus. Australian & New Zealand Journal of Ophthalmology; 23(2): 129-33.

36.   Lee LR, Sullivan TJ. (1995) Blepharophimosis Syndrome: Association with Optic, Retinochoroidal and Iris Coloboma, and Microphthalmos. Australian & New Zealand Journal of Ophthalmology; 23(2): 145-147.

37.   Lee LR, Sullivan TJ. (1995) Aspergillus Sphenoid Sinusitis Induced Orbital Apex Syndrome in HIV Infection. Australian & New Zealand Journal of Ophthalmology; 23(4): 327-331.

   

Dr Graham Lee

1.       Liang SYW, Lee GA, Shields D (2009).  Review: Self-tonometry in glaucoma management – past, present and future. Survey of Ophthalmology (In Press)

2.       Gilchrist H, Lee GA (2009).  Management of chalazia in general practice. Medicine Today (In Press)

3.       Alexander C, Lee GA, Whitehead K, Bashford J, Jefferies PD (2008).  Life threatening conjunctival presentation of myeloid sarcoma. Clinical & Experimental Ophthalmology (In Press)

4.       Smith TC, Lee GA (2008).  Conservative management of Pseudomonal infectious sclerokeratitis. Clinical & Experimental Optometry; 91:319-321

5.       Lee GA, Chen SX (2008).  Autologous serum in the management of recalcitrant dry eye syndrome. Clinical & Experimental Ophthalmology; 36:119-122.

6.       Pakrou N, Casson R, Fung S, Ferdowsi N, Lee GA, Selva D (2008).  South Australian Adolescent Ophthalmic Sun Protective Behaviours. Eye; 22: 808-814. 

7.       Cronin B, Todd B, Lee GA (2007).  The red eye in contact kens wearers – a high risk presentation. Australian Family Physician; 36:831-832.

8.       Chen SX, Lee GA (2007).  SmartPlug in the management of severe dry eye syndrome. Cornea; 26:534-8.

9.       Lee GA, Whitehead K, McDougall R (2007). Management of Paecilomyces keratitis. Eye; 21(2):262-4.

10.   Troutbeck R, Lee GA, Sanfilippo, Fleming B (2007). Trabeculectomy:  a training dilemma.  Eye; 21: 183-186.

11.   Farrah J, Lee GA, Greenrod E, Viera J (2006). Outcomes of autoconjunctival grafting for primary pterygia when performed by consultant compared with trainee ophthalmologists.  Clinical & Experimental Ophthalmology; 34:857-60.

12.   Sii F, Shah P, Lee GA (2006).  Minimising blinding complications of cyclodiode laser in high risk and only eyes.  Eye; 21(3):440-1.

13.   Holcombe D, Lee GA (2006).  Topical interferon for the treatment of recalcitrant ocular surface squamous neoplasia.  American Journal of Ophthalmology; 142:568-571.

14.   Rofail M, Lee GA, O’Rourke P (2006).  Quality of life following open globe injury. Ophthalmology; 113:1057.

15.   Rofail M, Lee GA, O’Rourke P (2006).  Prognostic indicators for open globe injuries. Clinical & Experimental Ophthalmology; 34:783-6.

16.   Lee GA, Hann JV, Braga-Mele R (2006).  Phacoemulsification in anterior megalophthalmos. Journal of Cataract and Refractive Surgery; 32:1081-4.

17.   Rofail M, Lee GA, Briner AM (2006).  Migratory intraocular cilium following phacoemulsification.  Clinical & Experimental Ophthalmology; 34:78-80.

18.   Paton GJ, Aquilina PJ, Lynham A, Lee GA (2006).  Intraocular pressure changes secondary to reduction of orbito-zygomatic complex fractures. Journal of Oral & Maxillofacial Surgery; 64:100-103.

19.   Sii F, Lee GA, Ficker LA (2006).  Recurrent pterygium as a cause of wound dehiscence in a corneal graft.  Eye; 20(5): 611-612.

20.   Lee GA, Chiang MY-M, Shah P (2006).  Pig eye trabeculectomy – a wet-lab teaching model. Eye; 21(1):32-37.

21.   Rofail M, Todd B, Lee LR, Lee GA (2005). Nail-gun penetrating eye injury.  Clinical & Experimental Ophthalmology; 33:294-5.

22.   Sii F, Lee GA (2005).  Fibrin glue in the management of corneal melt.  Clinical & Experimental Ophthalmology; 33:532-4.

23.   Sii F, Lee GA, Gole GA (2005).  Perforated corneal hydrops treated with sulphur hexafluoride (SF6) gas and tissue adhesive.  Cornea 24:503-504.

24.   Sii F, Lee GA, Sanfilippo P, Stephenson D (2004). Pellucid marginal degeneration and Scleroderma.  Clinical & Experimental Optometry; 87:180-184.

25.   Lee GA, Hilford DJ, Gole GA (2004).  Laser treatment of prethreshold and threshold retinopathy of prematurity. Clinical & Experimental Ophthalmology; 32:164-169.

26.   Griffiths M, Lee GA (2004).  Retained intraocular foreign body.  Clinical & Experimental Optometry; 87:34-6.

27.   Ooi SL, Lee GA (2003).  Argon laser trabeculoplasty: retrospective analysis of procedure rates and outcomes. Clinical & Experimental Ophthalmology (Proceedings); 31:15-6.

28.   Lee GA, Lee LR (2003).  Photodynamic therapy for age-related macular degeneration.  Medicine Today; 4:80-2.

29.   Lee GA, Peréz-Santonja JJ, Maloof A, Ficker LA, Dart JK (2003).  Effects of lamellar keratotomy on postkeratoplasty astigmatism. British Journal of Ophthalmology; 87:432-5.

30.   Lim KS, Lee GA, Ficker LA, Pavesio CE (2003).  Corneal melt and deafness as a presentation of Wegener’s granulomatosis.  British Journal of Ophthalmology; 87:500.

31.   Sanfilippo P, Lee GA (2003). Ocular cicatricial pemphigoid.  Clinical & Experimental Optometry; 86:47-50.

32.   Lee GA (2003). Cataract surgery – a guide for GPs and patients.  Medicine Today; 4:73-6.

33.   Lee GA, Shah P, Ficker LA, Khaw PT (2002).  Corneal thickness and intraocular pressure measurement – where are we now?  Clinical & Experimental Ophthalmology; 30:334-7.

34.   Lee GA, Gray TB, Dart JKG, Pavesio CE, Ficker LA, Larkin DFP (2002).  Acanthamoeba sclerokeratitis: treatment with systemic immunosuppression. Ophthalmology; 109:1178-1182.

35.   Lee GA (2002). Management of dry eye syndrome. Medicine Today; 3:87-90.

36.   Shah P, Lee GA, Kirwan JK, Ficker L, Khaw PT (2002).  Cyclodiode photocoagulation for refractory glaucoma after complicated penetrating keratoplasty.  Ophthalmology 108:1986-1991.

37.   Lee GA, Shah P, Cooling RJ, Dart JKG, Bunce C (2001).  Penetrating keratoplasty for silicone oil keratopathy.  Clinical & Experimental Journal of Ophthalmology 29:303-306.

38.   Peréz-Santonja JJ, Lee GA, Fulcher T, Dart JK (2001).  Acanthamoeba keratitis.  Comprehensive Ophthalmology Update 2(3);May-June.

39.   Lee GA, Hirst LW (1995).  Ocular surface squamous neoplasia.  Survey of Ophthalmology; 39: 429-450.  (Reviewed in “The Year Book of Ophthalmology, 1996, pp236-239, Current Opinion in Ophthalmology, 1996, p28).

40.   Lee GA, Williams G, Hirst LW, Green A (1994).  Risk factors in the development of ocular surface epithelial dysplasia.  Ophthalmology; 2:360-364.

41.   Lee GA, Hirst LW (1992).  Incidence of ocular surface epithelial dysplasia in metropolitan Brisbane: a ten year survey.  Archives of Ophthalmology; 10:525-527.

42.   Hirst LW, Lee GA (1998).  Corneo-scleral transplantation for end-stage corneal disease.  British Journal of Ophthalmology; 82:1276-1279.

43.   Lee GA, Lee LR, Gole GA (1998).  Angle closure glaucoma following laser treatment of retinopathy of prematurity - a case report.  Journal of the American Association for Pediatric Ophthalmology and Strabismus;  2(6):383-384.

44.   Lee GA, Hirst LW, Sheehan M (1994).  Knowledge of sunlight effects on the eyes and protective behaviours in the general community.  Ophthalmic Epidemiology; 1(2):1-18.

45.   Lee GA, Hirst LW, Sheehan M (1999).  Knowledge of sunlight effects on the eyes and protective behaviors in adolescents. Ophthalmic Epidemiology; 6(3):171-180.

46.   Lee GA, Cominos D, Sullivan TJ (1999).  Mucinous carcinoma of the eyelid.  Australian and New Zealand Journal of Ophthalmology; 27(1):71-73.

47.   Lee GA, Dal Pra M (1997).  Cracked acrylic intraocular lens requiring explantation. Australian and New Zealand Journal of Ophthalmology;  25(1):71-73.

48.   Lee GA, Sullivan TJ (1997).  Congenital orbital teratoma.  Australian and New Zealand Journal of Ophthalmology; 25(1):63-66.

49.   Lee GA, Hirst LW (1997).  A retrospective study of ocular surface squamous neoplasia.  Australian and New Zealand Journal of Ophthalmology; 25(4):269-276.

50.   Lee GA, Finnegan SJ, Bourke RD (1998).  Subretinal perfluorodecalin toxicity.  Australian and New Zealand Journal of Ophthalmology; 26(1):57-60.

51.   Feeney G, Lee GA, O’Connor PA (1999).  Quinine-induced blindness during attempted heroin withdrawal.  Medical Journal of Australia; 170(9):449.

52.   Lee GA, Bell A (1991).  An unusual breast lump.  Medical Journal of Australia; 155: 722-723.

 

Book Chapters

53.   Lee GA, Goldberg I.  Approach to cataract surgery in glaucoma patients in “Cataract Surgery in Glaucoma Patients”.  (In Press)

54.   Lee GA (2004-yearly).  Australian Medicines Handbook.  Chapter 11.  Eye Drugs

55.   Lee GA (2004-yearly).  Australian Medicines Handbook. Emergency and Primary Care. Eye

56.   Lee GA, Shah P (2001).  Ocular surface squamous neoplasia in “Key Topics in Ophthalmology – 2nd Edition.”  Oxford: Bios Scientific.

57.   Lee GA, Shah P, Taylor RH (2001).  Iridocorneal endothelial syndrome in “Key Topics in Ophthalmology – 2nd Edition.”  Oxford: Bios Scientific.

58.   Lee GA, Taylor RH, Shah P (2001).  Neurocristopathies in “Key Topics in Ophthalmology – 2nd Edition.”  Oxford: Bios Scientific.

 

Dr Jennifer Chen  

1.       Lee LR, Chen JC. (2008) Modified Cow-Hitch Suture Fixation. Cataract & Refractive Surgery Today Europe; 3(8): 14-15.

2.       Chen JC, Lee LR. (2008) Clinical spectrum of lamellar macular defects including pseudoholes and pseudocysts defined by optical coherence tomography. British Journal of Ophthalmology; 92(10): 1342-1346.

3.       Chen JC, Lee LR. (2008) A more coherent relationship to optical coherence tomography scans and retinal anatomy. Clinical and Experimental Optometry; 91(3): 328-329.

4.       Chen JC, Lee LR, Vorster, S. (2008) Spontaneous resolution of a stage III macular hole: a long-term follow-up with OCT. Retinal Cases & Brief Reports; 2(3):225-227.

5.       Chen JC, Lee LR, Vorster, S. (2008) Posterior Placoid Chorioretinitis: an unusual ocular manifestation of syphilis. Clinical Ophthalmology; 2(3): 669-674.

6.       Chen JC, Lee LR. (2007) Clinical applications and new developments of optical coherence tomography: an evidence-based review. Clinical and Experimental Optometry. 90(5); 317-335. (Issue Cover)

7.       Chen JC, Brown B, Schmid KL. (2006) Evaluation of inner retinal function in myopia using oscillatory potentials of the multifocal electroretinogram. Vision Research; 46(24): 4096-4103.

8.       Chen JC, Brown B, Schmid KL. (2006) Retinal adaptation responses revealed by global flash multifocal electroretinogram are dependent on the degree of myopic refractive error. Vision Research; 46(20): 3413-3421. (Issue Cover)

9.       Chen JC, Brown B, Schmid KL. (2006) Slow flash multifocal electroretinogram in myopia. Vision Research; 46(18): 2869-2876.

10.   Chen JC, Brown B, Schmid KL. (2006) Changes in implicit time of the multifocal electroretinogram response following contrast adaptation. Current Eye Research; 31: 549-556.

11.   Chen JC, Brown B, Schmid KL. (2006) Delayed mfERG responses in myopia. Vision Research; 46(8-9): 1221-1229.

12.   Chen JC, Lee LR, Gass JDM. (2006) Choroidal osteoma – evidence of progression and decalcification over 20 years. Clinical and Experimental Optometry; 89(2): 90-94. (Issue Cover)

13.   Chen JC, Brown B, Schmid KL. (2006) Multifocal oscillatory potentials of stable and progressing myopes. Ophthalmic and Physiological Optics; 26: 38.

14.   Chen JC, Lee LR. (2005) Central serous chorioretinopathy and bullous retinal detachment: a rare association. Clinical and Experimental Optometry; 88(4): 248-252. (Issue Cover)

15.   Chen JC, Schmid KL, Brown B, Edwards MH. (2005) The effect of a β-adrenoceptor antagonist on accommodative adaptation in Hong Kong children. Current Eye Research; 30: 1-10.

16.   Chen JC, Lee LR. (2005)  Solar retinopathy and associated optical coherence tomography findings. Clinical and Experimental Optometry; 87(6): 390-393

17.   Chen JC, Brown B, Schmid KL. (2004) Effect of unilateral forced nostril breathing on tonic accommodation and intraocular pressure. Clinical Autonomic Research; 14(6): 396-400.

18.   Chen JC, Schmid KL, Brown B.(2003) The autonomic control of accommodation and implications for human myopia development: a review. Ophthalmic & Physiological Optics; 23: 401-422.

19.   Chen JC, Schmid KL, Brown B, Edwards MH, Yu BSY, Lew JKF. (2003) AC/A ratios in myopic and emmetropic Hong Kong children and the effect of timolol. Clinical & Experimental Optometry; 86(5): 323-330.

20.   Chen JC, Fraser T, Fisher D, Khalil Z, Collins M, Hafner L. (2000) Characteristics of fungal growth in soft contact lenses. International Contact Lens Clinic; 26: 84-91.